Find all
associated with


Refine your query (more in Advanced-Search):
 Focus on the recent 5 years   Focus on the current year   Focus on the last 30 days   More choices ...
 Focus on articles with free fulltexts   More choices ...
 Do simple 'keyword' search (no query expansion)

[X] Close
You are about to erase all the values you have customized, search history, page format, etc.
Click here to RESET all values       Click here to GO BACK without resetting any value
Items 1 to 10 of about 383908

Advertisement
4. Chen XL, Zhang ML, Zhu L, Peng ML, Liu FZ, Zhang GX, Wang LM, Zhao J: Vitamin D receptor gene polymorphisms and the risk of multiple sclerosis: An updated meta-analysis. Microb Pathog; 2017 Sep;110:594-602
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Vitamin D receptor gene polymorphisms and the risk of multiple sclerosis: An updated meta-analysis.
  • BACKGROUND: The association between vitamin D receptor (VDR) gene polymorphisms and multiple sclerosis (MS) has been extensively studied, but results were controversial.
  • METHODS: This meta-analysis aimed to confirm whether VDR gene polymorphisms were associated with MS.
  • Meta-analysis on the association between MS and VDR ApaI, BsmI, TaqI and FokI polymorphisms were conducted using allelic contrast, recessive, homozygotes and dominant models.
  • RESULTS: A total of 21 relevant studies involving 3593 MS patients and 3917 controls were included in the analysis.
  • The association between TaqI polymorphism and MS risk was significant in the homozygous model (p = 0.006) indicated a significant protective effect of TT TaqI genotype.
  • High latitude (40.1-50°N) was also found markedly influenced TaqI polymorphism and MS risk in the recessive and homozygous models (p = 0.045 and p = 0.015, respectively).
  • Additionally, Asian or low latitude (20.1-30°N) people with ApaI homozygous genotype, '> 2013' publication year people in the allele contrast and dominant models of FokI, '> 40 years' age people with BsmI recessive model also indirectly significantly affected the association between VDR gene polymorphisms and MS risk.
  • CONCLUSION: TaqI polymorphism is a significant protective factor for MS.
  • However, the associations between ApaI, FokI and BsmI polymorphisms and MS were found only by study characteristics.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright © 2017 Elsevier Ltd. All rights reserved.
  • (PMID = 28780323.001).
  • [ISSN] 1096-1208
  • [Journal-full-title] Microbial pathogenesis
  • [ISO-abbreviation] Microb. Pathog.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Keywords] NOTNLM ; ApaI / BsmI / FokI / Meta-analysis / Multiple sclerosis / TaqI
  •  go-up   go-down


8. Cunningham S, Patterson CC, McDonnell G, Hawkins S, Vandenbroeck K: Haplotype analysis of the preprotachykinin-1 (TAC1) gene in multiple sclerosis. Genes Immun; 2005 May;6(3):265-70
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Haplotype analysis of the preprotachykinin-1 (TAC1) gene in multiple sclerosis.
  • The potential relevance of chromosome 7q21-22 in susceptibility to multiple sclerosis (MS) has been highlighted in genome-wide linkage screens as well as in association studies of 7q-specific polymorphic microsatellites.
  • Especially, recent, independently performed studies have provided evidence for significant association of the markers D7S554 and D7S3126 with MS in Sardinian, Northern Irish and Spanish-American cohorts.
  • The gene most closely located to these markers is the neuropeptide preprotachykinin-1 (TAC1) gene.
  • Both its position and the array of biological functions exerted by its expression products make it a logical primary choice for further scrutiny as the putative chromosome 7q21-22 MS susceptibility gene.
  • We report identification of eight polymorphisms in this gene by means of a sequencing approach.
  • One of these, an intron 1 single-nucleotide polymorphism (SNP), showed significant association with MS (P=0.009).
  • Two-marker haplotypes composed of allelic combinations of TAC1 promoter-intron 1 SNPs were highly significantly associated with MS and more so with the relapsing-remitting form of this disease.
  • While independent reproduction of these data in other data sets is indicated, our work is suggestive for a role of the TAC1 gene in MS.
  • Genes and Immunity (2005) 6, 265-270. doi:10.1038/sj.gene.6364175 Published online 24 February 2005.
  • [MeSH-major] Multiple Sclerosis / genetics. Protein Precursors / genetics. Tachykinins / genetics
  • [MeSH-minor] Genetic Predisposition to Disease. Haplotypes. Humans. Introns. Models, Genetic. Multiple Sclerosis, Relapsing-Remitting / genetics. Promoter Regions, Genetic

  • Genetic Alliance. consumer health - Multiple Sclerosis.
  • MedlinePlus Health Information. consumer health - Multiple Sclerosis.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15729363.001).
  • [ISSN] 1466-4879
  • [Journal-full-title] Genes and immunity
  • [ISO-abbreviation] Genes Immun.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Protein Precursors; 0 / Tachykinins; 0 / preprotachykinin
  •  go-up   go-down


9. Osoegawa M, Niino M, Ochi H, Kikuchi S, Murai H, Fukazawa T, Minohara M, Tashiro K, Kira J: Platelet-activating factor acetylhydrolase gene polymorphism and its activity in Japanese patients with multiple sclerosis. J Neuroimmunol; 2004 May;150(1-2):150-6
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Platelet-activating factor acetylhydrolase gene polymorphism and its activity in Japanese patients with multiple sclerosis.
  • We evaluated the association of the plasma platelet-activating factor acetylhydrolase (PAF-AH) gene polymorphism (G(994)-->T) and PAF-AH activity with susceptibility and severity of multiple sclerosis (MS) in Japanese.
  • DNA was collected from 216 patients with clinically definite MS (65 opticospinal MS (OS-MS) and 151 conventional MS (C-MS)) and from 213 healthy controls.
  • No statistically significant difference in the frequency of genotypes and alleles of the plasma PAF-AH polymorphism was observed among OS-MS patients, C-MS patients and healthy controls.
  • However, the missense mutation tended to be associated with the severity of OS-MS, especially in females (GT/TT genotypes; 51.7% in female rapidly progressive OS-MS vs. 26.6% in female controls, p=0.0870).
  • Moreover, PAF-AH activities were significantly lower in MS than in controls, irrespective of clinical subtypes, among those carrying the identical polymorphism in terms of nucleotide position 994 of the PAF-AH gene.
  • These findings suggest that the PAF-AH gene missense mutation has no relation to either susceptibility or severity of C-MS, yet its activity is down-regulated, and that the mutation has no relation with susceptibility of OS-MS, yet it may confer the severity of female OS-MS.
  • [MeSH-major] 1-Alkyl-2-acetylglycerophosphocholine Esterase / genetics. 1-Alkyl-2-acetylglycerophosphocholine Esterase / metabolism. Multiple Sclerosis / enzymology. Multiple Sclerosis / genetics. Polymorphism, Genetic
  • [MeSH-minor] Adult. Alleles. Asian Continental Ancestry Group. Enzyme Activation / genetics. Female. Gene Frequency. Gene Silencing. Genotype. Humans. Male. Middle Aged. Mutation, Missense. Neuromyelitis Optica / enzymology. Neuromyelitis Optica / genetics. Severity of Illness Index

  • Genetic Alliance. consumer health - Multiple Sclerosis.
  • MedlinePlus Health Information. consumer health - Multiple Sclerosis.
  • COS Scholar Universe. author profiles.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15081260.001).
  • [ISSN] 0165-5728
  • [Journal-full-title] Journal of neuroimmunology
  • [ISO-abbreviation] J. Neuroimmunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] EC 3.1.1.47 / 1-Alkyl-2-acetylglycerophosphocholine Esterase
  •  go-up   go-down


10. Alvarez R, Cour I, Kanaan A, Benedicto M, Martín-Estefanía C, Arroyo R, Varela de Seijas E, Picazo JJ: [Detection of viral genomes of the Herpesviridae family in multiple sclerosis patients by means of the polymerase chain reaction (PCR)]. Enferm Infecc Microbiol Clin; 2000 May;18(5):223-8
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Detection of viral genomes of the Herpesviridae family in multiple sclerosis patients by means of the polymerase chain reaction (PCR)].
  • [Transliterated title] Determinación de genomas de virus de la familia Herpesviridae en enfermos de esclerosis múltiple, por la reacción en cadena de la polimerasa (PCR).
  • BACKGROUND: The multiple sclerosis seems to be the junction between genetics alteration and an unknown environmental factor, that they would originate an autoimmune alteration, that they would be the reason of the inflammation and demyelinization responsible of the disease.
  • MATERIALS AND METHODS: 204 blood samples were studied: 102 from relapsing-remitting multiple sclerosis patients (43 were undergoing beta-interferon treatment), and 102 from blood donors with the same age and sex than multiple sclerosis patients.
  • RESULTS: a) we only found significative difference (p = 0.0001) in HHV-6: 21.5% donors positive samples (22/102), opposite to 49.02% of positivity in mulytiple sclerosis patients (50/102);.
  • CONCLUSIONS: Our results suggest us that HHV-6 can play an important role in the multiple sclerosis development.
  • [MeSH-major] DNA, Viral / blood. Genome, Viral. Herpesviridae / isolation & purification. Herpesviridae Infections / epidemiology. Multiple Sclerosis / virology. Polymerase Chain Reaction. Viremia / virology

  • Genetic Alliance. consumer health - Multiple Sclerosis.
  • MedlinePlus Health Information. consumer health - Multiple Sclerosis.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 10974766.001).
  • [ISSN] 0213-005X
  • [Journal-full-title] Enfermedades infecciosas y microbiología clínica
  • [ISO-abbreviation] Enferm. Infecc. Microbiol. Clin.
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] SPAIN
  • [Chemical-registry-number] 0 / Antiviral Agents; 0 / DNA, Viral; 77238-31-4 / Interferon-beta
  •  go-up   go-down






Advertisement