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1. Angrisani A, Matrone N, Belli V, Vicidomini R, Di Maio N, Turano M, Scialò F, Netti PA, Porcellini A, Furia M: A functional connection between dyskerin and energy metabolism. Redox Biol; 2018 Apr;14:557-565

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A functional connection between dyskerin and energy metabolism.
  • The human DKC1 gene encodes dyskerin, an evolutionarily conserved nuclear protein whose overexpression represents a common trait of many types of aggressive sporadic cancers.
  • As a crucial component of the nuclear H/ACA snoRNP complexes, dyskerin is involved in a variety of essential processes, including telomere maintenance, splicing efficiency, ribosome biogenesis, snoRNAs stabilization and stress response.
  • Although multiple minor dyskerin splicing isoforms have been identified, their functions remain to be defined.
  • Considering that low-abundance splice variants could contribute to the wide functional repertoire attributed to dyskerin, possibly having more specialized tasks or playing significant roles in changing cell status, we investigated in more detail the biological roles of a truncated dyskerin isoform that lacks the C-terminal nuclear localization signal and shows a prevalent cytoplasmic localization.
  • Here we show that this dyskerin variant can boost energy metabolism and improve respiration, ultimately conferring a ROS adaptive response and a growth advantage to cells.
  • These results reveal an unexpected involvement of DKC1 in energy metabolism, highlighting a previously underscored role in the regulation of metabolic cell homeostasis.

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  • [Copyright] Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.
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  • (PMID = 29132127.001).
  • [ISSN] 2213-2317
  • [Journal-full-title] Redox biology
  • [ISO-abbreviation] Redox Biol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Keywords] NOTNLM ; DKC1 / Energy metabolism / Mitochondria / PRDX-2 / ROS signaling
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2. Kumar MR, Farmer PJ: Chemical trapping and characterization of small oxoacids of sulfur (SOS) generated in aqueous oxidations of H<sub>2</sub>S. Redox Biol; 2018 Apr;14:485-491

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chemical trapping and characterization of small oxoacids of sulfur (SOS) generated in aqueous oxidations of H<sub>2</sub>S.
  • Small oxoacids of sulfur (SOS) are elusive molecules like sulfenic acid, HSOH, and sulfinic acid, HS(O)OH, generated during the oxidation of hydrogen sulfide, H<sub>2</sub>S, in aqueous solution.
  • Unlike their alkyl homologs, there is a little data on their generation and speciation during H<sub>2</sub>S oxidation.
  • These SOS may exhibit both nucleophilic and electrophilic reactivity, which we attribute to interconversion between S(II) and S(IV) tautomers.
  • We find that SOS may be trapped in situ by derivatization with nucleophilic and electrophilic trapping agents and then characterized by high resolution LC MS.
  • In this report, we compare SOS formation from H<sub>2</sub>S oxidation by a variety of biologically relevant oxidants.
  • These SOS appear relatively long lived in aqueous solution, and thus may be involved in the observed physiological effects of H<sub>2</sub>S.

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  • [Copyright] Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.
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  • (PMID = 29096321.001).
  • [ISSN] 2213-2317
  • [Journal-full-title] Redox biology
  • [ISO-abbreviation] Redox Biol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Keywords] NOTNLM ; And bromobimane / Dimedone / Hydrogen sulfide / Sulfenic acid / Sulfinic acid
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3. Henderson D, Huebner C, Markowitz M, Taube N, Harvanek ZM, Jakob U, Knoefler D: Do developmental temperatures affect redox level and lifespan in C. elegans through upregulation of peroxiredoxin? Redox Biol; 2018 Apr;14:386-390

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Do developmental temperatures affect redox level and lifespan in C. elegans through upregulation of peroxiredoxin?
  • Lifespan in poikilothermic organisms, such as Caenorhabditis elegans, can be substantially increased simply by decreasing growth temperature.
  • To gain insights into the mechanistic underpinnings of this effect, we investigated the effects of temperature in development and adulthood on C. elegans lifespan.
  • We found that worms exposed to 25°C during development and shifted to 15°C in adulthood exhibited an even longer lifespan than animals constantly kept at 15°C.
  • Analysis of the in vivo redox status demonstrated that at 25°C, C. elegans larvae have a more reduced redox state and higher Prdx-2 expression levels than animals raised at 15°C.
  • Worms lacking prdx-2 fail to show the additional lifespan extension upon shift from 25°C to 15°C and reveal a lifespan similar to prdx-2 worms always kept at 15°C.
  • These results suggest that transiently altering the in vivo redox state during development can have highly beneficial long-term consequences for organisms.

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  • [Copyright] Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.
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  • (PMID = 29055282.001).
  • [ISSN] 2213-2317
  • [Journal-full-title] Redox biology
  • [ISO-abbreviation] Redox Biol
  • [Language] eng
  • [Grant] United States / NIH HHS / OD / P40 OD010440; United States / NIA NIH HHS / AG / R01 AG027349; United States / NIGMS NIH HHS / GM / R35 GM122506
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Keywords] NOTNLM ; Aging / C. elegans / Oxidants / Peroxiredoxin / Temperature
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4. Heppner DE, Hristova M, Ida T, Mijuskovic A, Dustin CM, Bogdándi V, Fukuto JM, Dick TP, Nagy P, Li J, Akaike T, van der Vliet A: Cysteine perthiosulfenic acid (Cys-SSOH): A novel intermediate in thiol-based redox signaling? Redox Biol; 2018 Apr;14:379-385
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cysteine perthiosulfenic acid (Cys-SSOH): A novel intermediate in thiol-based redox signaling?
  • The reversible oxidation of protein cysteine residues (Cys-SH) is a key reaction in cellular redox signaling involving initial formation of sulfenic acids (Cys-SOH), which are commonly detected using selective dimedone-based probes.
  • Here, we report that significant portions of dimedone-tagged proteins are susceptible to cleavage by DTT reflecting the presence of perthiosulfenic acid species (Cys-SSOH) due to similar oxidation of hydropersulfides (Cys-SSH), since Cys-S-dimedone adducts are stable toward DTT.
  • Combined studies using molecular modeling, mass spectrometry, and cell-based experiments indicate that Cys-SSH are readily oxidized to Cys-SSOH, which forms stable adducts with dimedone-based probes.
  • We additionally confirm the presence of Cys-SSH within protein tyrosine kinases such as EGFR, and their apparent oxidation to Cys-SSOH in response NADPH oxidase activation, suggesting that such Cys-SSH oxidation may represent a novel, as yet uncharacterized, event in redox-based signaling.

  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
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  • [Copyright] Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.
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  • (PMID = 29054072.001).
  • [ISSN] 2213-2317
  • [Journal-full-title] Redox biology
  • [ISO-abbreviation] Redox Biol
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / F32 HL129706; United States / NIEHS NIH HHS / ES / R01 ES021476; United States / NHLBI NIH HHS / HL / R01 HL085646
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Keywords] NOTNLM ; Dimedone / Hydrogen peroxide / NADPH oxidase / Redox signaling / Sulfenic acid / Thiol oxidation
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5. Wang B, Yee Aw T, Stokes KY: N-acetylcysteine attenuates systemic platelet activation and cerebral vessel thrombosis in diabetes. Redox Biol; 2018 Apr;14:218-228

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] N-acetylcysteine attenuates systemic platelet activation and cerebral vessel thrombosis in diabetes.
  • OBJECTIVE: We previously demonstrated that diabetes exacerbates stroke-induced brain injury, and that this correlates with brain methylglyoxal (MG)-to-glutathione (GSH) status.
  • Cerebral injury was reversed by N-acetylcysteine (NAC).
  • Here we tested if the pro-thrombotic phenotype seen in the systemic circulation and brain during diabetes was associated with increased MG-glycation of proteins, and if NAC could reverse this.
  • METHODS: The streptozotocin (STZ)-induced mouse model of type 1 diabetes was used.
  • Thrombus formation in venules and arterioles (pial circulation) was determined by intravital videomicroscopy using the light-dye method.
  • Circulating blood platelet-leukocyte aggregates (PLAs) were analyzed by flow cytometry 1 wk before other measurements.
  • GSH and MG levels in platelets were measured by HPLC.
  • MG-modified proteins, glutathione peroxidase-1 (GPx-1), and superoxide dismutase-1 (SOD1) levels were detected in platelets by western blot at 20 weeks.
  • Proteins involved in coagulation were quantified by ELISA.
  • NAC (2mM) was given in drinking water for 3 weeks before the terminal experiment.
  • RESULTS: Thrombus development was accelerated by diabetes in a time-dependent manner.
  • % PLAs were significantly elevated by diabetes.
  • Plasma activated plasminogen activator inhibitor type 1 levels were progressively increased with diabetes duration, with tail bleeding time reduced by 20 wks diabetes.
  • Diabetes lowered platelet GSH levels, GPx-1 and SOD-1 expression.
  • This was associated with higher MG levels, and increased MG-adduct formation in platelets.
  • NAC treatment partly or completely reversed the effects of diabetes.
  • CONCLUSION: Collectively, these results show that the diabetic blood and brain become progressively more susceptible to platelet activation and thrombosis.
  • NAC, given after the establishment of diabetes, may offer protection against the risk for stroke by altering both systemic and vascular prothrombotic responses via enhancing platelet GSH, and GSH-dependent MG elimination, as well as correcting levels of antioxidants such as SOD1 and GPx-1.

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  • [Copyright] Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.
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  • (PMID = 28961512.001).
  • [ISSN] 2213-2317
  • [Journal-full-title] Redox biology
  • [ISO-abbreviation] Redox Biol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Keywords] NOTNLM ; Diabetes / Glutathione / Methylglyoxal / N-acetylcysteine / Thrombosis
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6. Cameron AR, Logie L, Patel K, Erhardt S, Bacon S, Middleton P, Harthill J, Forteath C, Coats JT, Kerr C, Curry H, Stewart D, Sakamoto K, Repiščák P, Paterson MJ, Hassinen I, McDougall G, Rena G: Metformin selectively targets redox control of complex I energy transduction. Redox Biol; 2018 Apr;14:187-197

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metformin selectively targets redox control of complex I energy transduction.
  • Many guanide-containing drugs are antihyperglycaemic but most exhibit toxicity, to the extent that only the biguanide metformin has enjoyed sustained clinical use.
  • Here, we have isolated unique mitochondrial redox control properties of metformin that are likely to account for this difference.
  • In primary hepatocytes and H4IIE hepatoma cells we found that antihyperglycaemic diguanides DG5-DG10 and the biguanide phenformin were up to 1000-fold more potent than metformin on cell signalling responses, gluconeogenic promoter expression and hepatocyte glucose production.
  • Each drug inhibited cellular oxygen consumption similarly but there were marked differences in other respects.
  • All diguanides and phenformin but not metformin inhibited NADH oxidation in submitochondrial particles, indicative of complex I inhibition, which also corresponded closely with dehydrogenase activity in living cells measured by WST-1.
  • Consistent with these findings, in isolated mitochondria, DG8 but not metformin caused the NADH/NAD<sup>+</sup> couple to become more reduced over time and mitochondrial deterioration ensued, suggesting direct inhibition of complex I and mitochondrial toxicity of DG8.
  • In contrast, metformin exerted a selective oxidation of the mitochondrial NADH/NAD<sup>+</sup> couple, without triggering mitochondrial deterioration.
  • Together, our results suggest that metformin suppresses energy transduction by selectively inducing a state in complex I where redox and proton transfer domains are no longer efficiently coupled.

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  • (PMID = 28942196.001).
  • [ISSN] 2213-2317
  • [Journal-full-title] Redox biology
  • [ISO-abbreviation] Redox Biol
  • [Language] eng
  • [Grant] United Kingdom / Wellcome Trust / /
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Keywords] NOTNLM ; Diabetes / Metformin / Mitochondria / NAD+ / NADH
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7. Quijada NM, De Filippis F, Sanz JJ, García-Fernández MDC, Rodríguez-Lázaro D, Ercolini D, Hernández M: Different Lactobacillus populations dominate in "Chorizo de León" manufacturing performed in different production plants. Food Microbiol; 2018 Apr;70:94-102

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Different Lactobacillus populations dominate in "Chorizo de León" manufacturing performed in different production plants.
  • "Chorizo de Léon" is a high-value Spanish dry fermented sausage traditionally manufactured without the use of starter cultures, owing to the activity of a house-specific autochthonous microbiota that naturally contaminates the meat from the environment, the equipment and the raw materials.
  • Lactic acid bacteria (particularly Lactobacillus) and coagulase-negative cocci (mainly Staphylococcus) have been reported as the most important bacterial groups regarding the organoleptic and safety properties of the dry fermented sausages.
  • In this study, samples from raw minced meat to final products were taken from five different producers and the microbial diversity was investigated by high-throughput sequencing of 16S rRNA gene amplicons.
  • The diverse microbial composition observed during the first stages of "Chorizo de Léon" evolved during ripening to a microbiota mainly composed by Lactobacillus in the final product.
  • Oligotyping performed on 16S rRNA gene sequences of Lactobacillus and Staphylococcus populations revealed sub-genus level diversity within the different manufacturers, likely responsible of the characteristic organoleptic properties of the products from different companies.

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  • [Copyright] Copyright © 2017 Elsevier Ltd. All rights reserved.
  • (PMID = 29173645.001).
  • [ISSN] 1095-9998
  • [Journal-full-title] Food microbiology
  • [ISO-abbreviation] Food Microbiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Keywords] NOTNLM ; Food fermentation / Lactobacillus / Microbial ecology / Oligotyping / Sequencing
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8. Rouger A, Moriceau N, Prévost H, Remenant B, Zagorec M: Diversity of bacterial communities in French chicken cuts stored under modified atmosphere packaging. Food Microbiol; 2018 Apr;70:7-16

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diversity of bacterial communities in French chicken cuts stored under modified atmosphere packaging.
  • Poultry meat, the second most consumed meat in France, is commercialized mainly as portions of chicken cuts with various quality labels, stored under various modified atmosphere packaging (MAP), with shelf-life ranging from 9 to 17 days.
  • We used 16S rDNA pyrosequencing to describe microbiota of chicken legs.
  • Ten samples representing a wide diversity of labels and MAP available on the market were collected from local supermarkets and stored at 4 °C.
  • Microbiota were collected, total DNA was extracted, and V1-V3 fragment of 16S rRNA genes were amplified and sequenced.
  • For data analysis several pipelines were compared.
  • The Qiime pipeline was chosen to cluster reads and we used a database previously developed for a meat and fish microbial ecology study.
  • Variability between samples was observed and a listing of bacteria present on chicken meat was established.
  • The structure of the bacterial communities were compared with traditional cultural methods and validated with quantitative real time PCR.
  • Brochothrix thermosphacta, Pseudomonas sp., and Carnobacterium sp. were dominant and the nature of the gas used for packaging influenced the relative abundance of each suggesting a MAP gas composition dependent competition between these species.
  • We also noticed that slaughterhouse environment may influence the nature of the contaminants.

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  • [Copyright] Copyright © 2017 Elsevier Ltd. All rights reserved.
  • (PMID = 29173642.001).
  • [ISSN] 1095-9998
  • [Journal-full-title] Food microbiology
  • [ISO-abbreviation] Food Microbiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Keywords] NOTNLM ; Chicken meat / Microbiota / Modified atmosphere packaging / Pyrosequencing / Spoilage
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9. Kuuliala L, Al Hage Y, Ioannidis AG, Sader M, Kerckhof FM, Vanderroost M, Boon N, De Baets B, De Meulenaer B, Ragaert P, Devlieghere F: Microbiological, chemical and sensory spoilage analysis of raw Atlantic cod (Gadus morhua) stored under modified atmospheres. Food Microbiol; 2018 Apr;70:232-244

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Microbiological, chemical and sensory spoilage analysis of raw Atlantic cod (Gadus morhua) stored under modified atmospheres.
  • During fish spoilage, microbial metabolism leads to the production of volatile organic compounds (VOCs), characteristic off-odors and eventual consumer rejection.
  • The aim of the present study was to contribute to the development of intelligent packaging technologies by identifying and quantifying VOCs that indicate spoilage of raw Atlantic cod (Gadus morhua) under atmospheres (%v/v CO<sub>2</sub>/O<sub>2</sub>/N<sub>2</sub>) 60/40/0, 60/5/35 and air.
  • Spoilage was examined by microbiological, chemical and sensory analyses over storage time at 4 or 8 °C.
  • Selected-ion flow-tube mass spectrometry (SIFT-MS) was used for quantifying selected VOCs and amplicon sequencing of the 16S rRNA gene was used for the characterization of the cod microbiota.
  • OTUs classified within the Photobacterium genus increased in relative abundance over time under all storage conditions, suggesting that Photobacterium contributed to spoilage and VOC production.
  • The onset of exponential VOC concentration increase and sensory rejection occurred at high total plate counts (7-7.5 log).
  • Monitoring of early spoilage thus calls for sensitivity for low VOC concentrations.

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  • [Copyright] Copyright © 2017 Elsevier Ltd. All rights reserved.
  • (PMID = 29173632.001).
  • [ISSN] 1095-9998
  • [Journal-full-title] Food microbiology
  • [ISO-abbreviation] Food Microbiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Keywords] NOTNLM ; Amplicon sequencing / Photobacterium / SIFT-MS / Sensor / Volatile organic compound
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10. Beccari G, Colasante V, Tini F, Senatore MT, Prodi A, Sulyok M, Covarelli L: Causal agents of Fusarium head blight of durum wheat (Triticum durum Desf.) in central Italy and their in vitro biosynthesis of secondary metabolites. Food Microbiol; 2018 Apr;70:17-27

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Causal agents of Fusarium head blight of durum wheat (Triticum durum Desf.) in central Italy and their in vitro biosynthesis of secondary metabolites.
  • Durum wheat samples harvested in central Italy (Umbria) were analyzed to: evaluate the occurrence of the fungal community in the grains, molecularly identify the Fusarium spp. which are part of the Fusarium head blight (FHB) complex and characterize the in vitro secondary metabolite profiles of a subset of Fusarium strains.
  • The Fusarium genus was one of the main components of the durum wheat fungal community.
  • The FHB complex was composed of eight species: Fusarium avenaceum (61%), F. graminearum (22%), F. poae (9%), F. culmorum (4%), F. proliferatum (2%), F. sporotrichioides (1%), F. sambucinum (0.5%) and F. langsethiae (0.5%). F. graminearum population was mainly composed of the 15-acetyldeoxynivalenol chemotype, while, F. culmorum population was composed of the 3-acetyldeoxynivalenol chemotype.
  • In vitro characterization of secondary metabolite biosynthesis was conducted for a wide spectrum of substances, showing the mycotoxigenic potential of the species complex. F. avenaceum strains were characterized by high enniantin and moniliformin production. F. graminearum strains were in prevalence deoxynivalenol producers. F. poae strains were characterized by a high biosynthesis of beauvericin like the F. sporotrichioides strain which was also found to be a high T-2/HT-2 toxins producer.
  • Production of aurofusarin, butenolide, gibepyrone D, fusarin C, apicidin was also reported for the analyzed strains.

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  • [Copyright] Copyright © 2017 Elsevier Ltd. All rights reserved.
  • (PMID = 29173624.001).
  • [ISSN] 1095-9998
  • [Journal-full-title] Food microbiology
  • [ISO-abbreviation] Food Microbiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Keywords] NOTNLM ; Cereals / FHB / Fungal community / In vitro analysis / Mycotoxins / Secondary metabolites
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