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Items 1 to 10 of about 1219691
1. Alnemri AM: Black lung persistent pulmonary hypertension of the newborn. Saudi experience with sildenafil and nitric oxide. Saudi Med J; 2017 Jan;38(1):97-100
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  • [Title] Black lung persistent pulmonary hypertension of the newborn. Saudi experience with sildenafil and nitric oxide.
  • OBJECTIVES: To determine the clinical presentation, risk factors, diagnosis, and treatment outcome of Saudi infants with black lung persistent pulmonary hypertension of the newborn (PPHN).
  • Only one infant required mechanical ventilation and inhaled nitric oxide in addition to oral sildenafil.

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  • (PMID = 28042638.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Saudi Arabia
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2. Guillen-Del Castillo A, Sánchez-Vidaurre S, Simeón-Aznar CP, Cruz MJ, Fonollosa-Pla V, Muñoz X: Prognostic Role of Exhaled Breath Condensate pH and Fraction Exhaled Nitric Oxide in Systemic Sclerosis Related Interstitial Lung Disease. Arch Bronconeumol; 2017 Mar;53(3):120-127
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  • [Title] Prognostic Role of Exhaled Breath Condensate pH and Fraction Exhaled Nitric Oxide in Systemic Sclerosis Related Interstitial Lung Disease.
  • [Transliterated title] Valor pronóstico del pH en el condensado de aire exhalado y de la fracción exhalada de óxido nítrico en la enfermedad pulmonar intersticial asociada a esclerosis sistémica.
  • METHODS: Fraction exhaled nitric oxide (FeNO) and exhaled carbon monoxide (eCO) measured in EB, together with pH, nitrite, nitrate and interleukin-6 levels measured in EBC were prospectively analyzed in 35 patients with SSc.
  • EB and EBC biomarkers were determined at inclusion, and pulmonary function tests were annually performed during 4 years of follow-up.
  • In all patients studied, low EBC pH levels were associated with a decreased diffusing capacity for carbon monoxide (DLCO) during follow-up.

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  • [Copyright] Copyright © 2016 SEPAR. Publicado por Elsevier España, S.L.U. All rights reserved.
  • (PMID = 28038794.001).
  • [ISSN] 1579-2129
  • [Journal-full-title] Archivos de bronconeumologia
  • [ISO-abbreviation] Arch. Bronconeumol.
  • [Language] eng; spa
  • [Publication-type] Journal Article
  • [Publication-country] Spain
  • [Keywords] NOTNLM ; Aire exhalado / Enfermedad pulmonar intersticial / Esclerosis sistémica / Exhaled breath / Interstitial lung disease / Nitric oxide / Systemic sclerosis / pH / Óxido nítrico
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3. Maccallini C, Amoroso R: Targeting neuronal nitric oxide synthase as a valuable strategy for the therapy of neurological disorders. Neural Regen Res; 2016 Nov;11(11):1731-1734
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  • [Title] Targeting neuronal nitric oxide synthase as a valuable strategy for the therapy of neurological disorders.
  • In this short review we analyze some promising advancements in the search of new bioactive molecules targeting neuronal nitric oxide synthase (nNOS), an enzyme deputed to the biosynthesis of nitric oxide (NO).

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  • (PMID = 28123402.001).
  • [ISSN] 1673-5374
  • [Journal-full-title] Neural regeneration research
  • [ISO-abbreviation] Neural Regen Res
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] India
  • [Keywords] NOTNLM ; NMDAR / PSD95 / amidines / carbonic anhydrase / inhibitors / neurological diseases / neuronal nitric oxide synthase
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4. Feng JX, Lin Y, Lin J, He SS, Chen MF, Wu XM, Xu YZ: Relationship between Fractional Exhaled Nitric Oxide Level and Efficacy of Inhaled Corticosteroid in Asthma-COPD Overlap Syndrome Patients with Different Disease Severity. J Korean Med Sci; 2017 Mar;32(3):439-447
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  • [Title] Relationship between Fractional Exhaled Nitric Oxide Level and Efficacy of Inhaled Corticosteroid in Asthma-COPD Overlap Syndrome Patients with Different Disease Severity.
  • This study explored the relationship between the fractional exhaled nitric oxide (FeNO) level and the efficacy of inhaled corticosteroid (ICS) in asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) patients with different disease severity.
  • We compared FeNO levels, pulmonary function parameters including percentage of forced expiratory volume in 1 second (FEV1) to predicted value (FEV1%pred), ratio of FEV1 to forced vital capacity (FEV1/FVC), inspiratory capacity to total lung capacity (IC/TLC) and residual volume to total lung capacity (RV/TLC), arterial blood gas parameters, including PH, arterial partial pressure of oxygen (PaO₂) and arterial partial pressure of carbon dioxide (PaCO₂), total serum immunoglobulin E (IgE), induced sputum eosinophil (EOS), plasma surfactant protein A (SP-A), plasma soluble receptor for advanced glycation end products (sRAGE), sputum myeloperoxidase (MPO), sputum neutrophil gelatinase-associated lipocalin (NGAL) and Asthma Control Test (ACT) scores, and COPD Assessment Test (CAT) scores.
  • [MeSH-major] Adrenal Cortex Hormones / therapeutic use. Asthma / drug therapy. Nitric Oxide / analysis. Pulmonary Disease, Chronic Obstructive / drug therapy
  • [MeSH-minor] Administration, Inhalation. Adult. Advanced Glycosylation End Product-Specific Receptor / blood. Aged. Biomarkers / blood. Biomarkers / metabolism. Blood Gas Analysis. Case-Control Studies. Female. Forced Expiratory Volume. Humans. Immunoglobulin E / blood. Lipocalin-2 / metabolism. Male. Middle Aged. Peroxidase / metabolism. Pulmonary Surfactant-Associated Protein A / blood. Respiratory Function Tests. Severity of Illness Index. Sputum / enzymology. Sputum / metabolism

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  • (PMID = 28145647.001).
  • [ISSN] 1598-6357
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Adrenal Cortex Hormones; 0 / Advanced Glycosylation End Product-Specific Receptor; 0 / Biomarkers; 0 / Lipocalin-2; 0 / Pulmonary Surfactant-Associated Protein A; 31C4KY9ESH / Nitric Oxide; 37341-29-0 / Immunoglobulin E; EC 1.11.1.7 / Peroxidase
  • [Keywords] NOTNLM ; Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome / Efficacy / Fractional Exhaled Nitric Oxide / Inhaled Corticosteroid
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5. Cao Z, Mathai SC, Hummers LK, Shah AA, Wigley FM, Lechtzin N, Hassoun PM, Girgis RE: Exhaled nitric oxide in pulmonary arterial hypertension associated with systemic sclerosis. Pulm Circ; 2016 Dec;6(4):545-550
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  • [Title] Exhaled nitric oxide in pulmonary arterial hypertension associated with systemic sclerosis.
  • : The fractional exhaled concentration of nitric oxide (FE<sub>NO</sub>) has been shown to be reduced in idiopathic pulmonary arterial hypertension (PAH) but has not been adequately studied in PAH associated with systemic sclerosis (SSc).
  • We measured FE<sub>NO</sub> at an expiratory flow rate of 50 mL/s in 21 treatment-naive patients with SSc-associated PAH (SSc-PAH), 94 subjects with SSc without pulmonary involvement, and 84 healthy volunteers.
  • Measurements of FE<sub>NO</sub> at additional flow rates of 100, 150, and 250 mL/s were obtained to derive the flow-independent nitric oxide exchange parameters of maximal airway flux (J'aw<sub>NO</sub>) and steady-state alveolar concentration (CA<sub>NO</sub>).
  • Increased alveolar nitric oxide in SSc-PAH likely represents impaired diffusion into pulmonary capillary blood.

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  • (PMID = 28090297.001).
  • [ISSN] 2045-8932
  • [Journal-full-title] Pulmonary circulation
  • [ISO-abbreviation] Pulm Circ
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; exhaled nitric oxide / pulmonary arterial hypertension / scleroderma / systemic sclerosis
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6. Zeng WP, Zhang R, Li R, Luo JF, Hu XF: Association of the Endothelial Nitric Oxide Synthase Gene T786C Polymorphism with In-Stent Restenosis in Chinese Han Patients with Coronary Artery Disease Treated with Drug-Eluting Stent. PLoS One; 2017;12(1):e0170964
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  • [Title] Association of the Endothelial Nitric Oxide Synthase Gene T786C Polymorphism with In-Stent Restenosis in Chinese Han Patients with Coronary Artery Disease Treated with Drug-Eluting Stent.
  • Genotyping was performed on six single nucleotide polymorphisms (SNPs) in the endothelial nitric oxide synthase gene (eNOS), the angiotensin converting enzyme gene (ACE), the angiotensin II type 1 receptor gene (AT1R), the transforming growth factor beta gene (TGF-β), and the vascular endothelial growth factor gene (VEGF).
  • Of the six analyzed SNPs, the frequency of the C allele of T786C polymorphism in eNOS was significantly higher in the ISR group (22.2%) compared to the non-ISR group (12.7%) (p<0.01).
  • In the ISR group, the frequency of the TT, TC, and CC genotypes was 61.1%, 33.3%, and 5.6%, respectively, and in the non-ISR group, the frequencies were 76.8%, 21.0%, and 2.2%, respectively.

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  • (PMID = 28129392.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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7. Wiwanitkit V: Nitric oxide synthase and polycystic kidney disease. J Nephropharmacol; 2015;4(2):85-87
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  • [Title] Nitric oxide synthase and polycystic kidney disease.

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  • (PMID = 28197487.001).
  • [Journal-full-title] Journal of nephropharmacology
  • [ISO-abbreviation] J Nephropharmacol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Iran
  • [Keywords] NOTNLM ; Chronic kidney disease / Nitric oxide synthase / Polycystic kidney disease
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8. Deng DD, Zhou AY, Shuang QC, Chen P: [The value of fractionated exhaled nitric oxide in the diagnosis of asthma-chronic obstructive pulmonary disease overlap syndrome]. Zhonghua Jie He He Hu Xi Za Zhi; 2017 Feb 12;40(2):98-101
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  • [Title] [The value of fractionated exhaled nitric oxide in the diagnosis of asthma-chronic obstructive pulmonary disease overlap syndrome].
  • : <b>Objective:</b> To explore the diagnostic value of fractionated exhaled nitric oxide (FeNO) measurement in patients with asthma-chronic obstructive pulmonary disease(COPD) overlap syndrome (ACOS).
  • <b>Methods:</b> Eighty-one patients with ACOS, 76 patients with asthma, 82 patients with COPD and 39 healthy non-smoking subjects were recruited in the study.
  • Pulmonary function was also measured.

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  • (PMID = 28209039.001).
  • [ISSN] 1001-0939
  • [Journal-full-title] Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases
  • [ISO-abbreviation] Zhonghua Jie He He Hu Xi Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Keywords] NOTNLM ; Asthma / Asthma-COPD overlap syndrome / Nitric oxide / Pulmonary disease, chronic obstructive
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9. Madhu BP, Singh KP, Saminathan M, Singh R, Shivasharanappa N, Sharma AK, Malik YS, Dhama K, Manjunatha V: Role of nitric oxide in the regulation of immune responses during rabies virus infection in mice. Virusdisease; 2016 Dec;27(4):387-399
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  • [Title] Role of nitric oxide in the regulation of immune responses during rabies virus infection in mice.
  • : Rabies virus (RABV) stimulates nitric oxide (NO) production, which either triggers T cell differentiation or suppresses T cell function depending on its concentration.
  • The experimental animals were divided into four groups and 100LD<sub>50</sub> of challenge virus standard (CVS) strain of RABV was inoculated intracerebrally on day 0 and subsequently aminoguanidine (AG; inducible nitric oxide synthase inhibitor) was injected intraperitoneally twice a day, up to 6 days.

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  • (PMID = 28004019.001).
  • [ISSN] 2347-3584
  • [Journal-full-title] Virusdisease
  • [ISO-abbreviation] Virusdisease
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Keywords] NOTNLM ; Aminoguanidine / CD4+ / CD8+ T lymphocytes / Challenge virus standard strain / Natural killer cells / Rabies virus
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10. Ohtake K, Ehara N, Chiba H, Nakano G, Sonoda K, Ito J, Uchida H, Kobayashi J: Dietary nitrite reverses features of postmenopausal metabolic syndrome induced by high-fat diet and ovariectomy in mice. Am J Physiol Endocrinol Metab; 2017 Apr 01;312(4):E300-E308
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  • Menopausal women are at greater risk of developing metabolic syndrome with reduced endothelial nitric oxide synthase (eNOS) activity.
  • We hypothesized that nitric oxide (NO) supplementation should have a therapeutic effect on this syndrome.
  • OVX and HF significantly reduced plasma levels of nitrate/nitrite (NOx), and mice developed obesity with visceral hypertrophic adipocytes and increased transcriptional levels of monocyte chemoattractant protein-1, TNF-α, and IL-6 in visceral fat tissues.
  • These results suggest that an endogenous NO defect might underlie postmenopausal metabolic syndrome and that dietary nitrite provides an alternative source of NO, subsequently compensating for metabolic impairments of this syndrome.

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  • [Copyright] Copyright © 2017 the American Physiological Society.
  • (PMID = 28196859.001).
  • [ISSN] 1522-1555
  • [Journal-full-title] American journal of physiology. Endocrinology and metabolism
  • [ISO-abbreviation] Am. J. Physiol. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; metabolic syndrome / nitric oxide / nitrite / ovariectomy / postmenopause
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