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Items 1 to 10 of about 307553
1. Mack HG, Tien MC, White OB: Acute Anterior Uveitis in a Patient Taking Fingolimod (FTY720) for Multiple Sclerosis. Case Rep Ophthalmol; 2016 Sep-Dec;7(3):284-288
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Acute Anterior Uveitis in a Patient Taking Fingolimod (FTY720) for Multiple Sclerosis.
  • Fingolimod is an oral sphingosine-1-phosphate (S1P) receptor modulator and the first oral therapy for relapsing-remitting multiple sclerosis.
  • We report the case of a 34-year-old male with relapsing-remitting multiple sclerosis, who developed acute anterior uveitis on day 5 of fingolimod treatment.

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  • (PMID = 28101047.001).
  • [Journal-full-title] Case reports in ophthalmology
  • [ISO-abbreviation] Case Rep Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Keywords] NOTNLM ; FTY720 / Fingolimod / Rebound syndrome / Relapsing-remitting multiple sclerosis / Uveitis
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2. Clottu AS, Mathias A, Sailer AW, Schluep M, Seebach JD, Du Pasquier R, Pot C: EBI2 Expression and Function: Robust in Memory Lymphocytes and Increased by Natalizumab in Multiple Sclerosis. Cell Rep; 2017 Jan 03;18(1):213-224
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  • [Title] EBI2 Expression and Function: Robust in Memory Lymphocytes and Increased by Natalizumab in Multiple Sclerosis.
  • : The interaction between oxysterols and the G protein-coupled receptor Epstein-Barr virus-induced gene 2 (EBI2) fine-tunes immune cell migration, a mechanism efficiently targeted by several disease-modifying treatments developed to treat multiple sclerosis (MS), such as natalizumab.
  • We previously showed that memory CD4<sup>+</sup> T lymphocytes migrate specifically in response to 7α,25-dihydroxycholesterol (7α,25-OHC) via EBI2 in the MS murine model experimental autoimmune encephalomyelitis.
  • However, the EBI2 expression profile in human lymphocytes in both healthy and MS donors is unknown.
  • These data suggest a significant role for EBI2 in human CD4<sup>+</sup> T cell migration, notably in patients with MS.
  • Better knowledge of EBI2 involvement in autoimmunity may therefore lead to an improved understanding of the physiopathology of MS.

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  • [Copyright] Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.
  • (PMID = 28052250.001).
  • [ISSN] 2211-1247
  • [Journal-full-title] Cell reports
  • [ISO-abbreviation] Cell Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; G protein-coupled receptor Epstein-Barr virus-induced gene 2 (EBI2) / lymphocyte trafficking / multiple sclerosis / natalizumab / oxysterols
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3. Duque P, Oltra-Cucarella J, Fernandez O, Sepulcre J, Grupo de Estudio de la Bateria Neuropsicologica Breve En la Esclerosis Multiple GE: [Brief Neuropsychological Battery for multiple sclerosis. Normative data stratified by age and educational level]. Rev Neurol; 2017 Feb 01;64(3):97-104
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Brief Neuropsychological Battery for multiple sclerosis. Normative data stratified by age and educational level].
  • [Transliterated title] Bateria neuropsicologica breve en la esclerosis multiple. Baremacion normativa estratificada por edad y nivel educativo.
  • INTRODUCTION: Interpretation of the performance on cognitive tests for neuropsychological assessment in multiple sclerosis (MS) differs according to the educational level of the examinee.
  • AIMS: To provide normative data for the Brief Neuropsychological Battery (BNB) for MS stratified by age and education, as well as to demonstrate the utility of the battery for discriminating between healthy controls and patients with MS.
  • SUBJECTS AND METHODS: Data from 701 healthy volunteers from the original normative sample were stratified by age and education using regression analyses of standard scores.
  • Performance of the healthy control group was compared to a group of 112 patients with MS.
  • CONCLUSIONS: Our data indicate that the BNB for MS is sensitive for identifying cognitive impairments in MS, specifically in tasks measuring working memory.

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  • (PMID = 28128426.001).
  • [ISSN] 1576-6578
  • [Journal-full-title] Revista de neurologia
  • [ISO-abbreviation] Rev Neurol
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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4. Ramasamy R, Joseph B, Whittall T: Potential molecular mimicry between the human endogenous retrovirus W family envelope proteins and myelin proteins in multiple sclerosis. Immunol Lett; 2017 Mar;183:79-85
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Potential molecular mimicry between the human endogenous retrovirus W family envelope proteins and myelin proteins in multiple sclerosis.
  • Multiple sclerosis is an autoimmune disease caused by the destruction of the myelin sheath in the central nervous system.
  • The major target molecules for the immune response are the myelin basic protein, myelin oligodendrocyte glycoprotein and proteolipid protein but the aetiology of the disease is as yet poorly understood.
  • The HLA Class II allele DRB1*1501 in particular as well as DRB5*0101 and the expression of human endogenous retroviral envelope proteins have been linked to multiple sclerosis but the molecular mechanisms relating these remain to be elucidated.
  • We hypothesised that cross-reactive peptide epitopes in retroviral envelope proteins and myelin proteins that can be presented by the two Class II DR molecules may play a role in initiating multiple sclerosis.
  • The results support the hypothesis that molecular mimicry in peptide epitopes from envelope proteins of the HERV-W family of endogenous retroviruses and myelin proteins is possible and could potentially trigger multiple sclerosis.
  • Mimicry between syncytin-1, a HERV-W envelope protein that is expressed during placentation, and myelin proteins may also explain the higher prevalence of multiple sclerosis in women.

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  • [Copyright] Copyright © 2017 European Federation of Immunological Societies. Published by Elsevier B.V. All rights reserved.
  • (PMID = 28189601.001).
  • [ISSN] 1879-0542
  • [Journal-full-title] Immunology letters
  • [ISO-abbreviation] Immunol. Lett.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Keywords] NOTNLM ; Autoimmunity / HLA DR2(15) haplotype / Human endogenous retroviruses / Molecular mimicry / Multiple sclerosis / Myelin proteins
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5. Gromisch ES, Schairer LC, Pasternak E, Kim SH, Foley FW: Assessment and Treatment of Psychiatric Distress, Sexual Dysfunction, Sleep Disturbances, and Pain in Multiple Sclerosis: A Survey of Members of the Consortium of Multiple Sclerosis Centers. Int J MS Care; 2016 Nov-Dec;18(6):291-297
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  • [Title] Assessment and Treatment of Psychiatric Distress, Sexual Dysfunction, Sleep Disturbances, and Pain in Multiple Sclerosis: A Survey of Members of the Consortium of Multiple Sclerosis Centers.
  • : <b>Background:</b> Psychiatric distress (depression and anxiety), sexual dysfunction, sleep disturbances, and pain are frequent comorbidities in multiple sclerosis (MS) that have the potential to interfere with functioning and quality of life.
  • To better understand current practices, this study aimed to gain a multidisciplinary perspective on how MS providers assess and treat these five problems.
  • <b>Methods:</b> An online questionnaire was completed by 42 members of the Consortium of Multiple Sclerosis Centers on their assessment procedures, treatment recommendations, and prevalence rates of these issues in their practices.
  • <b>Conclusions:</b> Health-care providers are aware of the prevalence of these issues in their patients with MS.

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  • (PMID = 27999523.001).
  • [ISSN] 1537-2073
  • [Journal-full-title] International journal of MS care
  • [ISO-abbreviation] Int J MS Care
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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6. Edwards T, Klaren RE, Motl RW, Pilutti LA: Further characterization and validation of the oxygen uptake efficiency slope for persons with multiple sclerosis. J Rehabil Med; 2017 Feb 24;
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  • [Title] Further characterization and validation of the oxygen uptake efficiency slope for persons with multiple sclerosis.
  • OBJECTIVE: To further characterize the oxygen uptake efficiency slope (OUES) in persons with multiple sclerosis through a direct comparison with matched controls, and by examining differences across the multiple sclerosis disability spectrum.
  • Also, to validate the OUES as an alternative method, which can be derived from submaximal exercise testing, for expressing cardiorespiratory fitness in persons with mild-to-severe multiple sclerosis.
  • PARTICIPANTS: A total of 62 participants (Expanded Disability Status Scale (EDSS) = 1.5-6.5) with MS and 21 non-multiple sclerosis controls completed a symptom-limited cardiopulmonary exercise test.
  • RESULTS: The OUES was significantly lower in persons with multiple sclerosis (mean 1,708.5 (standard deviation (SD) 503.7)) compared with non-multiple sclerosis controls (mean 2074.2 (SD 823.2)).
  • With regards to the multiple sclerosis sample, there was a significant difference in the OUES (F[2,59] = 8.9, p < 0.001, ηρ2 = 0.23) across the multiple sclerosis disability spectrum.
  • CONCLUSION: Overall, the OUES is a viable method for expressing cardiorespiratory fitness in individuals with multiple sclerosis, and submaximal OUES is an appropriate alternative when maximal exercise testing is not feasible.

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  • (PMID = 28233011.001).
  • [ISSN] 1651-2081
  • [Journal-full-title] Journal of rehabilitation medicine
  • [ISO-abbreviation] J Rehabil Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Sweden
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7. Passerini G, Dalla Costa G, Sangalli F, Moiola L, Colombo B, Locatelli M, Comi G, Furlan R, Martinelli V: Free Light Chains and Intrathecal B Cells Activity in Multiple Sclerosis: A Prospective Study and Meta-Analysis. Mult Scler Int; 2016;2016:2303857
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  • [Title] Free Light Chains and Intrathecal B Cells Activity in Multiple Sclerosis: A Prospective Study and Meta-Analysis.
  • The presence of CSF oligoclonal bands (OBs) is an independent prognostic factor for multiple sclerosis (MS), but the difficulties in the standardization of the test and the interlaboratory variation in reporting have contributed to its limited use in the diagnosis of the disease.
  • The presence of OBs, kappa and lambda FLC levels, and standard indices of intrathecal inflammation were assessed in 100 consecutive patients, including patients with MS, clinically isolated syndromes (CIS), other inflammatory diseases of the CNS, and other noninflammatory diseases. <i>Results</i>.
  • KFLC and LFLC were significantly different in patients with MS and CIS compared to the other groups (<i>p</i> < 0.001 and <i>p</i> < 0.001, resp.) and had a better diagnostic accuracy than all the other tests (area under the curve 82.3 % for KFLC index and 79.3 % for LFLC index). <i>Conclusion</i>.
  • Nephelometric assays for KFLC in CSF reliably detect intrathecal immunoglobulin synthesis and discriminate MS patients.

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  • (PMID = 28116160.001).
  • [ISSN] 2090-2654
  • [Journal-full-title] Multiple sclerosis international
  • [ISO-abbreviation] Mult Scler Int
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
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8. Mostafa A, Jalilvand S, Shoja Z, Nejati A, Shahmahmoodi S, Sahraian MA, Marashi SM: Multiple sclerosis-associated retrovirus, Epstein-barr virus, and vitamin D status in patients with relapsing remitting multiple sclerosis. J Med Virol; 2017 Feb 06;
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multiple sclerosis-associated retrovirus, Epstein-barr virus, and vitamin D status in patients with relapsing remitting multiple sclerosis.
  • The levels of multiple sclerosis-associated retrovirus (MSRV)-type DNA of Env gene was measured in peripheral blood mononuclear cells from 52 patients with relapsing-remitting multiple sclerosis (RRMS) and 40 healthy controls using specific quantitative PCR (qPCR) analysis.
  • Interestingly, an inverse correlation was found between MSRV DNA copy number and serum vitamin D concentration (p< 0.01), but not for EBV load or anti-EBNA-1 IgG antibody.

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  • [Copyright] This article is protected by copyright. All rights reserved.
  • (PMID = 28165135.001).
  • [ISSN] 1096-9071
  • [Journal-full-title] Journal of medical virology
  • [ISO-abbreviation] J. Med. Virol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; Epstein-bar virus / Human endogenous retrovirus / multiple sclerosis associated retrovirus / relapsing remitting multiple sclerosis / vitamin D
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9. Hervault M, Balto JM, Hubbard EA, Motl RW: Reliability, precision, and clinically important change of the Nine-Hole Peg Test in individuals with multiple sclerosis. Int J Rehabil Res; 2017 Mar;40(1):91-93
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Reliability, precision, and clinically important change of the Nine-Hole Peg Test in individuals with multiple sclerosis.
  • Sixty-nine patients with multiple sclerosis completed the 9-HPT on two occasions 1 week apart.
  • Test-retest reliability was based on intraclass correlation coefficient, and precision was based on standard error of measurement and coefficient of variation.
  • Intraclass correlation coefficients exceed 0.90 for all 9-HPT metrics.
  • Coefficient of variations for DH and NDH time were 4.3 and 3.8%, and 4.5 and 4.6% for DH and NDH speed.
  • These data provide evidence on reliability, precision, and clinically important change of the 9-HPT over a 1-week period in multiple sclerosis for clinicians and researchers.

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  • (PMID = 28059944.001).
  • [ISSN] 1473-5660
  • [Journal-full-title] International journal of rehabilitation research. Internationale Zeitschrift fur Rehabilitationsforschung. Revue internationale de recherches de readaptation
  • [ISO-abbreviation] Int J Rehabil Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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10. Zandian A, Forsström B, Häggmark-Månberg A, Schwenk JM, Uhlén M, Nilsson P, Ayoglu B: Whole-Proteome Peptide Microarrays for Profiling Autoantibody Repertoires within Multiple Sclerosis and Narcolepsy. J Proteome Res; 2017 Feb 09;
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Whole-Proteome Peptide Microarrays for Profiling Autoantibody Repertoires within Multiple Sclerosis and Narcolepsy.
  • A set of ten plasma and serum samples from subjects with multiple sclerosis, narcolepsy, and without any disease diagnosis were profiled on a peptide array representing the whole proteome, hosting 2.2 million 12-mer peptides with a six amino acid lateral shift.
  • The presented workflow employed three different peptide microarray formats to discover and resolve the epitopes of human autoantibodies and revealed two potentially new autoantigens: MAP3K7 in multiple sclerosis and NRXN1 in narcolepsy.

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  • (PMID = 28121444.001).
  • [ISSN] 1535-3907
  • [Journal-full-title] Journal of proteome research
  • [ISO-abbreviation] J. Proteome Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; autoantibody profiling / epitope mapping / multiple sclerosis / narcolepsy / peptide microarrays
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