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Items 1 to 10 of about 312486
1. Türkoğlu R, Giriş M, Gencer M, Akcan U, Örçen A: Serum Prolactin Levels in Multiple Sclerosis, Neuromyelitis Optica, and Clinically Isolated Syndrome Patients. Noro Psikiyatr Ars; 2016 Dec;53(4):353-356

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Serum Prolactin Levels in Multiple Sclerosis, Neuromyelitis Optica, and Clinically Isolated Syndrome Patients.
  • INTRODUCTION: Prolactin has been discussed as a factor likely to play a mediating role in multiple sclerosis (MS).
  • METHODS: Serum prolactin levels of 255 MS patients, 19 neuromyelitis optica (NMO) patients, 15 clinically isolated syndrome (CIS) patients, and 240 healthy controls were measured by a heterogeneous sandwich magnetic separation assay.
  • RESULTS: MS and NMO cohorts had a significantly higher number of patients with hyperprolactinemia than healthy controls.
  • Sera obtained during attacks of both MS and NMO patients displayed higher prolactin levels than those collected during remission.
  • Prolactin level elevations were found to be more prominent in myelitis attacks in MS.
  • No significant correlation was found between prolactin levels and age, disease duration, disability status, number of attacks, and oligoclonal band positivity.
  • CIS patients who converted to MS had higher prolactin levels than those who did not.
  • CONCLUSION: Our findings support the possible mediating role of prolactin in the immunopathogenesis of MS, NMO, and conversion from CIS to MS.

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  • (PMID = 28360812.001).
  • [ISSN] 1300-0667
  • [Journal-full-title] Noro psikiyatri arsivi
  • [ISO-abbreviation] Noro Psikiyatr Ars
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Turkey
  • [Keywords] NOTNLM ; Prolactin / clinically isolated syndrome / multiple sclerosis / neuromyelitis optica
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2. Haibing X, Xu C, Jifu C, Wenshuang Z, Ling L, Yuzhen C, Yanjun H: Correlation between CTLA-4 gene rs221775A>G single nucleotide polymorphism and multiple sclerosis susceptibility. A meta-analysis. Open Med (Wars); 2016;11(1):264-269

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Correlation between CTLA-4 gene rs221775A>G single nucleotide polymorphism and multiple sclerosis susceptibility. A meta-analysis.
  • OBJECTIVE: The aim of this meta-analysis was to undertake a meta-analysis to evaluate the correlation between cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) gene rs221775 A>G single nucleotide polymorphism and the susceptibility of multiple sclerosis (MS) susceptibility.
  • METHOD: Published manuscripts about CTLA-4 gene rs221775A>G single nucleotide polymorphism and multiple sclerosis susceptibility were searched in the computerized bibliographic searches of Pubmed Embase and China National Knowledge Infrastructure (CNKI).
  • Potential studies were screened and data for 5025 MS patients and 4706 controls from 20 publications were included.
  • The association between CTLA-4 gene rs221775A>G single nucleotide polymorphism and multiple sclerosis susceptibility were demonstrated by odds ratio (OR) and 95% confidence interval (95%CI).
  • RESULTS: The pooled results showed no significant association between CTLA-4 gene rs221775A>G single nucleotide polymorphism and multiple sclerosis susceptibility for dominant genetic model [OR=1.02, 95%CI:0.90~1.05, (P=0.80)], homozygous genetic model [OR=0.85,95%CI:0.71 ~1.03,(P=0.10)] and recessive genetic model [OR=0.99,95% CI:0.89~1.10,(P=0.90)].
  • CONCLUSION: With current evidence, CTLA-4 gene rs221775A>G single nucleotide polymorphism had no association with the susceptibility of multiple sclerosis.

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  • (PMID = 28352806.001).
  • [Journal-full-title] Open medicine (Warsaw, Poland)
  • [ISO-abbreviation] Open Med (Wars)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
  • [Keywords] NOTNLM ; CTLA-4 gene / Meta-analysis / Multiple sclerosis / Polymorphism / Susceptibility
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3. Duque P, Oltra-Cucarella J, Fernandez O, Sepulcre J, Grupo de Estudio de la Bateria Neuropsicologica Breve En la Esclerosis Multiple GE: [Brief Neuropsychological Battery for multiple sclerosis. Normative data stratified by age and educational level]. Rev Neurol; 2017 Feb 01;64(3):97-104

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Brief Neuropsychological Battery for multiple sclerosis. Normative data stratified by age and educational level].
  • [Transliterated title] Bateria neuropsicologica breve en la esclerosis multiple. Baremacion normativa estratificada por edad y nivel educativo.
  • INTRODUCTION: Interpretation of the performance on cognitive tests for neuropsychological assessment in multiple sclerosis (MS) differs according to the educational level of the examinee.
  • AIMS: To provide normative data for the Brief Neuropsychological Battery (BNB) for MS stratified by age and education, as well as to demonstrate the utility of the battery for discriminating between healthy controls and patients with MS.
  • SUBJECTS AND METHODS: Data from 701 healthy volunteers from the original normative sample were stratified by age and education using regression analyses of standard scores.
  • Performance of the healthy control group was compared to a group of 112 patients with MS.
  • CONCLUSIONS: Our data indicate that the BNB for MS is sensitive for identifying cognitive impairments in MS, specifically in tasks measuring working memory.

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  • (PMID = 28128426.001).
  • [ISSN] 1576-6578
  • [Journal-full-title] Revista de neurologia
  • [ISO-abbreviation] Rev Neurol
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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4. Savic RM, Novakovic AM, Ekblom M, Munafo A, Karlsson MO: Population Pharmacokinetics of Cladribine in Patients with Multiple Sclerosis. Clin Pharmacokinet; 2017 03 02;

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Population Pharmacokinetics of Cladribine in Patients with Multiple Sclerosis.
  • METHODS: This population PK analysis was based on the combined dataset from four clinical studies in patients with multiple sclerosis (MS): three phase I studies, including one food and one drug-drug interaction study, and one phase III clinical study.
  • RESULTS: The analysis comprised a total of 2619 CdA and CAde plasma and urine concentration observations from 173 patients with MS who received an intravenous infusion or oral tablet doses of CdA as a single agent or in combination with interferon (IFN) β-1a.
  • CdA renal clearance (CL<sub>R</sub>) was correlated with creatinine clearance (CL<sub>CR</sub>), predicting a decrease in the total clearance of 19%, 30% and 40% for patients with mild (CL<sub>CR</sub> = 65 ml/min), moderate (CL<sub>CR</sub> = 40 ml/min) and severe (CL<sub>CR</sub> = 20 ml/min) renal impairment, respectively.

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  • (PMID = 28255849.001).
  • [ISSN] 1179-1926
  • [Journal-full-title] Clinical pharmacokinetics
  • [ISO-abbreviation] Clin Pharmacokinet
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT00213135
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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5. Zare L, Sheikh Fathollahi M, Kazemi Arababadi M, Shamsizadeh A, Daneshpajouh B, Zainodini N, Allahtavakoli M: The Association Between C424c/A Polymorphism Within the IL-25 Gene and Multiple Sclerosis. Iran Red Crescent Med J; 2016 Sep;18(9):e25995

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The Association Between C424c/A Polymorphism Within the IL-25 Gene and Multiple Sclerosis.
  • BACKGROUND: Multiple Sclerosis (MS) is a common autoimmune system disease which affects the central nervous system.
  • It has been documented that interleukin-25 (IL-25) plays key roles in suppressing Th1 responses, which is increased during MS.
  • OBJECTIVES: The aim of this study was to investigate the c424C/A polymorphism within the IL-25 gene in MS patients in comparison to healthy controls.
  • PATIENTS AND METHODS: In this case-control study, 74 patients with MS and 75 healthy controls were selected.
  • Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) was used in order to determine c424C/A polymorphism within the IL-25 gene.
  • RESULTS: The results showed that there was no statistical significant difference in distribution of genotype (AA, AC and CC) and allele (A and C) frequencies between MS patients and healthy controls (P = 0.901 and P = 0.728, respectively).
  • CONCLUSIONS: In conclusion, it appears that the c424C/A polymorphism within the IL-25 gene has no significant relationship with MS, and this polymorphism is probably not associated with MS complications, its onset and gender distribution.

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  • (PMID = 28144453.001).
  • [ISSN] 2074-1804
  • [Journal-full-title] Iranian Red Crescent medical journal
  • [ISO-abbreviation] Iran Red Crescent Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United Arab Emirates
  • [Keywords] NOTNLM ; CCL25 / Genetic / Multiple Sclerosis / Polymorphism
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6. Passerini G, Dalla Costa G, Sangalli F, Moiola L, Colombo B, Locatelli M, Comi G, Furlan R, Martinelli V: Free Light Chains and Intrathecal B Cells Activity in Multiple Sclerosis: A Prospective Study and Meta-Analysis. Mult Scler Int; 2016;2016:2303857

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Free Light Chains and Intrathecal B Cells Activity in Multiple Sclerosis: A Prospective Study and Meta-Analysis.
  • The presence of CSF oligoclonal bands (OBs) is an independent prognostic factor for multiple sclerosis (MS), but the difficulties in the standardization of the test and the interlaboratory variation in reporting have contributed to its limited use in the diagnosis of the disease.
  • The presence of OBs, kappa and lambda FLC levels, and standard indices of intrathecal inflammation were assessed in 100 consecutive patients, including patients with MS, clinically isolated syndromes (CIS), other inflammatory diseases of the CNS, and other noninflammatory diseases. <i>Results</i>.
  • KFLC and LFLC were significantly different in patients with MS and CIS compared to the other groups (<i>p</i> < 0.001 and <i>p</i> < 0.001, resp.) and had a better diagnostic accuracy than all the other tests (area under the curve 82.3 % for KFLC index and 79.3 % for LFLC index). <i>Conclusion</i>.
  • Nephelometric assays for KFLC in CSF reliably detect intrathecal immunoglobulin synthesis and discriminate MS patients.

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  • (PMID = 28116160.001).
  • [ISSN] 2090-2654
  • [Journal-full-title] Multiple sclerosis international
  • [ISO-abbreviation] Mult Scler Int
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
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7. Cardamone G, Paraboschi EM, Rimoldi V, Duga S, Soldà G, Asselta R: The Characterization of GSDMB Splicing and Backsplicing Profiles Identifies Novel Isoforms and a Circular RNA That Are Dysregulated in Multiple Sclerosis. Int J Mol Sci; 2017 Mar 07;18(3)
MedlinePlus Health Information. consumer health - Multiple Sclerosis.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The Characterization of GSDMB Splicing and Backsplicing Profiles Identifies Novel Isoforms and a Circular RNA That Are Dysregulated in Multiple Sclerosis.
  • In particular, a growing body of evidence suggests the existence of a pathogenic association between a generalized defect in splicing regulatory genes and multiple sclerosis (MS).
  • Moreover, several studies have documented an unbalance in alternatively-spliced isoforms in MS patients possibly contributing to the disease etiology.
  • In this work, using a combination of PCR-based techniques (reverse-transcription (RT)-PCR, fluorescent-competitive, real-time, and digital RT-PCR assays), we investigated the alternatively-spliced gene encoding Gasdermin B, <i>GSDMB</i>, which was repeatedly associated with susceptibility to asthma and AIDs.
  • Importantly, both AS isoforms and the identified ecircRNA were significantly dysregulated in peripheral blood mononuclear cells of relapsing-remitting MS patients compared to controls, further supporting the notion that aberrant RNA metabolism is a characteristic feature of the disease.
  • [MeSH-major] Gene Expression Regulation. Multiple Sclerosis / genetics. Neoplasm Proteins / genetics. RNA. RNA Splicing
  • [MeSH-minor] Alternative Splicing. Case-Control Studies. Exons. Female. Gene Order. Humans. Male. Multiple Sclerosis, Relapsing-Remitting / blood. Multiple Sclerosis, Relapsing-Remitting / genetics. Nonsense Mediated mRNA Decay

  • Genetic Alliance. consumer health - Multiple Sclerosis.
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  • (PMID = 28272342.001).
  • [ISSN] 1422-0067
  • [Journal-full-title] International journal of molecular sciences
  • [ISO-abbreviation] Int J Mol Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / GSDMB protein, human; 0 / Neoplasm Proteins; 0 / RNA, circular; 63231-63-0 / RNA
  • [Keywords] NOTNLM ; GSDMB / alternative splicing / circRNA / multiple sclerosis / nonsense-mediated mRNA decay
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8. Shinoda K, Matsushita T, Nakamura Y, Masaki K, Yamasaki R, Yamaguchi H, Togao O, Hiwatashi A, Kira JI: HLA-DRB1*04:05 allele is associated with intracortical lesions on three-dimensional double inversion recovery images in Japanese patients with multiple sclerosis. Mult Scler; 2017 May 01;:1352458517707067

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] HLA-DRB1*04:05 allele is associated with intracortical lesions on three-dimensional double inversion recovery images in Japanese patients with multiple sclerosis.
  • BACKGROUND: Cortical lesions (CLs) frequently observed in Caucasian patients with multiple sclerosis (MS) contribute to disability.
  • However, it remains unclear whether CLs are associated with clinical features and genetic risk factors, such as HLA-DRB1*15:01 and -DRB1*04:05 in Asian MS patients.
  • OBJECTIVE: To elucidate the frequency of CLs and their association with HLA-DRB1 and DPB1 alleles in Japanese MS patients.
  • METHODS: Three-dimensional double inversion recovery imaging and clinical information were retrospectively obtained from 92 Japanese MS patients.
  • MS patients with ICLs had a significantly higher frequency of secondary progression and greater Expanded Disability Status Scale (EDSS) scores than those without ICLs.
  • The number of all three lesion types positively correlated with EDSS scores.
  • CONCLUSION: ICLs are associated with greater disease severity in Japanese MS patients and are partly suppressed by the HLA-DRB1*04:05 allele.

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  • (PMID = 28474969.001).
  • [ISSN] 1477-0970
  • [Journal-full-title] Multiple sclerosis (Houndmills, Basingstoke, England)
  • [ISO-abbreviation] Mult. Scler.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Keywords] NOTNLM ; HLA-DRB1*04:05 / HLA-DRB1*15:01 / Japanese / cortical lesion / double inversion recovery image / intracortical lesion
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9. Liu G, Hu Y, Jin S, Jiang Q: Genetic variant rs763361 regulates multiple sclerosis CD226 gene expression. Proc Natl Acad Sci U S A; 2017 Feb 07;114(6):E906-E907

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Genetic variant rs763361 regulates multiple sclerosis CD226 gene expression.

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  • (PMID = 28137889.001).
  • [ISSN] 1091-6490
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] eng
  • [Publication-type] Letter
  • [Publication-country] United States
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10. Farrokhi M, Masoudifar A, Derakhshan A, Saadatmand S, Rouhi-Boroujeni H, Etemadifar M, Rezaei-Zarji S, Javid A, Nobakht R, Deyhimi M, Ekramnia A, Ebrahimi M, Sheikh S, Ansaripour S, Amani-Beni A, Jahanbani-Ardakani H: The Association of Interleukin-16 Gene Polymorphisms with IL-16 Serum Levels and Risk of Multiple Sclerosis. Immunol Invest; 2017 Feb 02;:1-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The Association of Interleukin-16 Gene Polymorphisms with IL-16 Serum Levels and Risk of Multiple Sclerosis.
  • BACKGROUND: Multiple sclerosis (MS) is a chronic inflammatory, demyelinating, and neurodegenerative disease of the central nervous system (CNS) that is immunologically mediated in genetically susceptible individuals.
  • Single-nucleotide polymorphisms (SNPs) in the IL-16 gene may lead to altered cytokine expression or biological activity, and these variations may modulate an individual's risk for MS.
  • To test this hypothesis, we investigated association of IL-16 gene SNPs (i.e., rs4072111 C/T, rs11556218 G/T, and rs4778889 C/T) and serum IL-16 levels with risk of MS in an Iranian population.
  • METHODS: We analyzed the three SNPs of IL-16 in 250 MS patients and 400 healthy controls using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
  • The serum level of IL-16 was assessed by enzyme-linked immunosorbent assay (ELISA).
  • RESULTS: The IL-16 rs4072111C/T genotype and allele frequencies showed significantly differences between MS patients and controls (p < 0.01).
  • The mean serum levels of IL-16 in MS patients were significantly higher in MS patients compared to healthy controls (p ≤ 0.01).
  • CONCLUSION: In summary, the present study provides the first evidence that the rs11556218T/G and rs4072111C/T polymorphisms of IL-16 gene were significantly associated with increased risk of MS.
  • These results suggest that rs11556218T/G, rs4072111C/T, and rs4778889T/C polymorphisms of IL-16 may contribute to susceptibility to MS through increased expression of IL-16 levels.

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  • (PMID = 28151028.001).
  • [ISSN] 1532-4311
  • [Journal-full-title] Immunological investigations
  • [ISO-abbreviation] Immunol. Invest.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Keywords] NOTNLM ; ELISA / interleukin-16 / multiple sclerosis / polymerase chain reaction / polymorphism
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