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Items 1 to 10 of about 4961
1. Kim TE, Ha N, Kim Y, Kim H, Lee JW, Jeon JY, Kim MG: Effect of epigallocatechin-3-gallate, major ingredient of green tea, on the pharmacokinetics of rosuvastatin in healthy volunteers. Drug Des Devel Ther; 2017;11:1409-1416

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effect of epigallocatechin-3-gallate, major ingredient of green tea, on the pharmacokinetics of rosuvastatin in healthy volunteers.
  • Previous in vitro studies have demonstrated the inhibitory effect of green tea on drug transporters.
  • Because rosuvastatin, a lipid-lowering drug widely used for the prevention of cardiovascular events, is a substrate for many drug transporters, there is a possibility that there is interaction between green tea and rosuvastatin.
  • The aim of this study was to investigate the effect of green tea on the pharmacokinetics of rosuvastatin in healthy volunteers.
  • After a 3-day washout period, the subjects received 20 mg of rosuvastatin plus 300 mg of epigallocatechin-3-gallate (EGCG), a major ingredient of green tea (Day 4).

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  • (PMID = 28533679.001).
  • [ISSN] 1177-8881
  • [Journal-full-title] Drug design, development and therapy
  • [ISO-abbreviation] Drug Des Devel Ther
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] New Zealand
  • [Keywords] NOTNLM ; EGCG / drug interaction / drug transporter / green tea / pharmacokinetics / rosuvastatin
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2. Guo Y, Zhi F, Chen P, Zhao K, Xiang H, Mao Q, Wang X, Zhang X: Green tea and the risk of prostate cancer: A systematic review and meta-analysis. Medicine (Baltimore); 2017 Mar;96(13):e6426
Hazardous Substances Data Bank. Green tea .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Green tea and the risk of prostate cancer: A systematic review and meta-analysis.
  • Among these foods, green tea is considered as effective prevention for various cancers.
  • However, clinical trials and previous meta-analyses on the relationship between green tea consumption and the risk of PCa have produced inconsistent outcomes.
  • This study aims to determine the dose-response association of green tea intake with PCa risk and the preventive effect of green tea catechins on PCa risk.
  • Dose-response relations were evaluated with categories of green tea intake.
  • Although there was no statistical significance in the comparison of the highest versus lowest category, there was a trend of reduced incidence of PCa with each 1 cup/day increase of green tea (P = 0.08).
  • Our dose-response meta-analysis further demonstrated that higher green tea consumption was linearly associated with a reduced risk of PCa with more than 7 cups/day.
  • In addition, green tea catechins were effective for preventing PCa with an RR of 0.38 (P = 0.02).
  • In conclusion, our dose-response meta-analysis evaluated the association of green tea intake with PCa risk systematically and quantitatively.
  • And this is the first meta-analysis of green tea catechins consumption and PCa incidence.
  • Our novel data demonstrated that higher green tea consumption was linearly reduced PCa risk with more than 7 cups/day and green tea catechins were effective for preventing PCa.
  • [MeSH-major] Carcinoma / prevention & control. Catechin / therapeutic use. Prostatic Neoplasms / prevention & control. Tea

  • Genetic Alliance. consumer health - Prostate cancer.
  • MedlinePlus Health Information. consumer health - Prostate Cancer.
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  • (PMID = 28353571.001).
  • [ISSN] 1536-5964
  • [Journal-full-title] Medicine
  • [ISO-abbreviation] Medicine (Baltimore)
  • [Language] eng
  • [Publication-type] Journal Article; Meta-Analysis; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tea; 8R1V1STN48 / Catechin
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3. Seo EJ, Wu CF, Ali Z, Wang YH, Khan SI, Walker LA, Khan IA, Efferth T: Both Phenolic and Non-phenolic Green Tea Fractions Inhibit Migration of Cancer Cells. Front Pharmacol; 2016;7:398

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Both Phenolic and Non-phenolic Green Tea Fractions Inhibit Migration of Cancer Cells.
  • Green tea consumption is associated with chemoprevention of many cancer types.
  • Fresh tea leaves are rich in polyphenolic catechins, which can constitute up to 30% of the dry leaf weight.
  • While the polyphenols of green tea have been well investigated, it is still largely unknown, whether or not non-phenolic constituents also reveal chemopreventive and anti-metastatic effects.
  • In this study, we investigated the effects of a fraction of green tea rich in phenolic compounds (PF), a non-phenolic fraction (NPF), which contains glyceroglycolipids (GGL), and a pure glyceroglycolipid compound isolated from the non-phenolic fraction in human cancer.
  • Dried green tea leaves were extracted and applied to a Sephadex LH-20 column.
  • The resazurin reduction assay was used to investigate the cytotoxicity of green tea samples toward human HepG2 hepatocellular carcinoma and normal AML12 hepatocytes cells.
  • The scratch migration assay was used to investigate the effects of green tea samples on cell migration <i>in vitro</i>.
  • PF and NPF were prepared from methanol extract of green tea.
  • All three green tea samples did not show significant cytotoxic activity up to 10 μg/mL in both HepG2 and AML12 cells, whereas cytotoxicity of the control drug doxorubicin was observed with both cell lines (IC<sub>50</sub> on AML12: 0.024 μg/mL, IC<sub>50</sub> on HepG2: 2.103 μg/mL).
  • We identified three sets of genes differentially expressed upon treatment with the green tea samples.
  • HepG2 and U2OS cells treated with green tea extracts showed the delayed closures.
  • Besides, the number of distinct tubulin filaments decreased upon treatment with green tea samples.
  • We identified not only PF, but also glyceroglycolipids in NPF as contributing factors to the chemopreventive effects of green tea.
  • Both PF and NPF of green tea inhibited cancer cell migration by the disassembly of microtubules, even though they were not cytotoxic.

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  • (PMID = 28194107.001).
  • [ISSN] 1663-9812
  • [Journal-full-title] Frontiers in pharmacology
  • [ISO-abbreviation] Front Pharmacol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Keywords] NOTNLM ; chemoprevention / green tea / microarray / nutrigenomics / theaceae
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4. Ni CX, Gong H, Liu Y, Qi Y, Jiang CL, Zhang JP: Green Tea Consumption and the Risk of Liver Cancer: A Meta-Analysis. Nutr Cancer; 2017 Feb-Mar;69(2):211-220

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Green Tea Consumption and the Risk of Liver Cancer: A Meta-Analysis.
  • : Green tea is a commonly consumed beverage in Asia and has been suggested to have anticarcinogenic properties.
  • To date, epidemiological evidence of the effect of green tea consumption on liver cancer risk remains ambiguous.
  • The aim of this meta-analysis is to evaluate the association between green tea consumption and the risk of liver cancer.
  • The summary relative risk for the highest consumption (≥5 cups/day) of green tea on liver cancer incidence compared with nondrinkers was 0.62 (95% confidence interval: 0.49-0.79).
  • We also found a trend that the incidence of liver cancer was reduced with the increasing years of green tea intake (significance at >20 yr).
  • A significant dose-response association was found between green tea drinking and liver cancer risk.
  • The downward trend was most obvious when the consumption of green tea increased up to about 4 cups/day.
  • The results showed that the increasing green tea intake may have a preventive effect against liver cancer.

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  • (PMID = 28095030.001).
  • [ISSN] 1532-7914
  • [Journal-full-title] Nutrition and cancer
  • [ISO-abbreviation] Nutr Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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5. Azimi S, Mansouri Z, Bakhtiari S, Tennant M, Kruger E, Rajabibazl M, Daraei A: Does green tea consumption improve the salivary antioxidant status of smokers? Arch Oral Biol; 2017 Jun;78:1-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Does green tea consumption improve the salivary antioxidant status of smokers?
  • OBJECTIVE: 
Considering the higher rate of oral cancer, and reduction in salivary antioxidants in smokers as indicated in previous studies, antioxidant- containing nutrients such as green tea, seem to be beneficial in counteracting against oxidative stress in this group.
  • This study assessed the salivary total antioxidant alteration in smokers compared to nonsmokers, after short-tem (7days) and long-term (3 weeks), green tea drinking.
  • Participants were instructed to drink two cups of green tea per day, by dissolving 2g of green tea in 150ml of hot water for each cup.
  • There was also a significant difference between two groups in salivary total antioxidant capacity after one week and three weeks of green tea consumption (P<0.001).
  • However, there was an upward trend in both smokers and non-smokers over the study period (after tea drinking).
  • CONCLUSIONS: Results support the effectiveness of green tea consumption in salivary antioxidants enhancement in smokers, in both the short- and long term.

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  • [Copyright] Copyright © 2017 Elsevier Ltd. All rights reserved.
  • (PMID = 28189030.001).
  • [ISSN] 1879-1506
  • [Journal-full-title] Archives of oral biology
  • [ISO-abbreviation] Arch. Oral Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Keywords] NOTNLM ; Antioxidant capacity / Green tea / Saliva / Smokers
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6. Tan Y, Kim J, Cheng J, Ong M, Lao WG, Jin XL, Lin YG, Xiao L, Zhu XQ, Qu XQ: Green tea polyphenols ameliorate non-alcoholic fatty liver disease through upregulating AMPK activation in high fat fed Zucker fatty rats. World J Gastroenterol; 2017 Jun 07;23(21):3805-3814
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Green tea polyphenols ameliorate non-alcoholic fatty liver disease through upregulating AMPK activation in high fat fed Zucker fatty rats.
  • AIM: To investigate protective effects and molecular mechanisms of green tea polyphenols (GTP) on non-alcoholic fatty liver disease (NAFLD) in Zucker fatty (ZF) rats.

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  • (PMID = 28638220.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; AMP-activated protein kinase / Green tea polyphenols / Hepatic lipogenesis / Inflammatory cytokines / Non-alcoholic fatty liver disease
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7. Park JH, Bae JH, Im SS, Song DK: Green tea and type 2 diabetes. Integr Med Res; 2014 Mar;3(1):4-10

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Green tea and type 2 diabetes.
  • Green tea and coffee consumption have been widely popular worldwide.
  • In addition to this caffeine effect, green tea and coffee consumption have always been at the center of discussions about human health, disease, and longevity.
  • In particular, green tea catechins are involved in many biological activities such as antioxidation and modulation of various cellular lipid and proteins.
  • Some reports also suggest that daily consumption of tea catechins may help in controlling type 2 diabetes.
  • However, other studies have reported that chronic consumption of green tea may result in hepatic failure, neuronal damage, and exacerbation of diabetes, suggesting that interindividual variations in the green tea effect are large.
  • This review will focus on the effect of green tea catechins extracted from the <i>Camellia sinensis</i> plant on type 2 diabetes and obesity, and the possible mechanistic explanation for the experimental results mainly from our laboratory.
  • It is hoped that green tea can be consumed in a suitable manner as a supplement to prevent the development of type 2 diabetes and obesity.

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  • (PMID = 28664072.001).
  • [ISSN] 2213-4220
  • [Journal-full-title] Integrative medicine research
  • [ISO-abbreviation] Integr Med Res
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Keywords] NOTNLM ; catechins / glucose uptake / green tea / obesity / type 2 diabetes
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8. Xie X, Yi W, Zhang P, Wu N, Yan Q, Yang H, Tian C, Xiang S, Du M, Getachew Assefa E, Zuo X, Ying C: Green Tea Polyphenols, Mimicking the Effects of Dietary Restriction, Ameliorate High-Fat Diet-Induced Kidney Injury via Regulating Autophagy Flux. Nutrients; 2017 May 14;9(5)

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Green Tea Polyphenols, Mimicking the Effects of Dietary Restriction, Ameliorate High-Fat Diet-Induced Kidney Injury via Regulating Autophagy Flux.
  • Epidemiological and experimental studies reveal that Western dietary patterns contribute to chronic kidney disease, whereas dietary restriction (DR) or dietary polyphenols such as green tea polyphenols (GTPs) can ameliorate the progression of kidney injury.

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  • (PMID = 28505110.001).
  • [ISSN] 2072-6643
  • [Journal-full-title] Nutrients
  • [ISO-abbreviation] Nutrients
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Keywords] NOTNLM ; autophagy / dietary restriction / green tea polyphenols / high-fat diet / renal function
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9. Dekant W, Fujii K, Shibata E, Morita O, Shimotoyodome A: Safety assessment of green tea based beverages and dried green tea extracts as nutritional supplements. Toxicol Lett; 2017 Aug 05;277:104-108

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Safety assessment of green tea based beverages and dried green tea extracts as nutritional supplements.
  • The safety of green tea infusions and green tea extract (GTE)-based products is reviewed regarding catechins.
  • Epigallocatechin 3-gallate (EGCG), the major catechin present in green tea, is suspected of being responsible for liver toxicity reported in humans consuming food supplements.
  • Intake of EGCG with green tea infusions and GTE-based beverages is up to about 450mg EGCG/person/day in Europe and higher in Asia.
  • Consumption of green tea is not associated with liver damage in humans, and green tea infusion and GTE-based beverages are considered safe in the range of historical uses.
  • Use of NOAELs from bolus administration to derive a tolerable upper intake level applying the margin of safety concept results in acceptable EGCG-doses lower than those from one cup of green tea.
  • Thus, a tolerable upper intake level of 300mg EGCG/person/day is proposed for food supplements; this gives a twofold safety margin to clinical studies that did not report liver effects and a margin of safety of 100 to the NOAELs in animal studies with dietary administration of green tea catechins.
  • [MeSH-major] Camellia sinensis / chemistry. Catechin / analogs & derivatives. Dietary Supplements. Food Safety. Plant Extracts / analysis. Tea / chemistry. Teas, Herbal / analysis
  • [MeSH-minor] Animals. Consumer Product Safety. Hazard Analysis and Critical Control Points. Humans. No-Observed-Adverse-Effect Level. Recommended Dietary Allowances. Risk Assessment

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  • [Copyright] Copyright © 2017 Elsevier B.V. All rights reserved.
  • (PMID = 28655517.001).
  • [ISSN] 1879-3169
  • [Journal-full-title] Toxicology letters
  • [ISO-abbreviation] Toxicol. Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Plant Extracts; 0 / Tea; 0 / Teas, Herbal; 8R1V1STN48 / Catechin; BQM438CTEL / epigallocatechin gallate
  • [Keywords] NOTNLM ; Catechins / Food supplements / Green tea / Safety assessment
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10. Lazzeroni M, Guerrieri-Gonzaga A, Gandini S, Johansson H, Serrano D, Cazzaniga M, Aristarco V, Macis D, Mora S, Caldarella P, Pagani G, Pruneri G, Riva A, Petrangolini G, Morazzoni P, DeCensi A, Bonanni B: A Presurgical Study of Lecithin Formulation of Green Tea Extract in Women with Early Breast Cancer. Cancer Prev Res (Phila); 2017 Jun;10(6):363-370

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A Presurgical Study of Lecithin Formulation of Green Tea Extract in Women with Early Breast Cancer.
  • Epidemiologic data support an inverse association between green tea intake and breast cancer risk.
  • Greenselect Phytosome (GSP) is a lecithin formulation of a caffeine-free green tea catechin extract.

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  • [Copyright] ©2017 American Association for Cancer Research.
  • (PMID = 28400479.001).
  • [ISSN] 1940-6215
  • [Journal-full-title] Cancer prevention research (Philadelphia, Pa.)
  • [ISO-abbreviation] Cancer Prev Res (Phila)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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